公开(公告)号：US11414453B2

公开(公告)日：2022-08-16

申请号：US17392170

申请日：2021-08-02

申请人： TriLink Biotechnologies, LLC

发明人： Richard I. Hogrefe ,  Alexandre Lebedev ,  Anton P. McCaffrey ,  Dongwon Shin

IPC分类号： C07H21/02 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/711 ,  A23L33/13 ,  C12N15/11 ,  C12P19/34

摘要： Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.

公开(公告)号：US11578095B2

公开(公告)日：2023-02-14

申请号：US17804192

申请日：2022-05-26

申请人： TriLink Biotechnologies, LLC

发明人： Richard I. Hogrefe ,  Alexandre Lebedev ,  Anton P. McCaffrey ,  Dongwon Shin

IPC分类号： C07H21/02 ,  A61K31/7115 ,  A61K31/712 ,  A61K31/711 ,  A23L33/13 ,  C12N15/11 ,  C12P19/34

摘要： Provided herein are methods and compositions for synthesizing 5′Capped RNAs wherein the initiating capped oligonucleotide primers have the general form m7Gppp[N2′Ome]n[N]m wherein m7G is N7-methylated guanosine or any guanosine analog, N is any natural, modified or unnatural nucleoside, “n” can be any integer from 0 to 4 and “m” can be an integer from 1 to 9.