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公开(公告)号:US20240180952A1
公开(公告)日:2024-06-06
申请号:US18285063
申请日:2022-03-31
IPC分类号: A61K31/711 , A61K9/00 , A61K39/00 , C07K16/28
CPC分类号: A61K31/711 , A61K9/0019 , C07K16/2818 , A61K2039/505
摘要: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating primary liver cancers such as hepatocellular carcinoma (HCC) and intra-hepatic cholangiocarcinoma (ICC) comprising administering TLR9 agonists to the liver.
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公开(公告)号:US20230364125A1
公开(公告)日:2023-11-16
申请号:US18027883
申请日:2021-09-21
IPC分类号: A61K31/7125 , A61K9/00 , A61P35/04 , A61K45/06
CPC分类号: A61K31/7125 , A61K9/0019 , A61K45/06 , A61P35/04
摘要: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the liver using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating metastases of uveal melanoma of the liver comprising administering TLR9 agonists to the liver.
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公开(公告)号:US20230374523A1
公开(公告)日:2023-11-23
申请号:US18027895
申请日:2021-09-21
IPC分类号: C12N15/117 , A61K39/395 , A61K39/39 , A61P35/00
CPC分类号: C12N15/117 , A61K39/39558 , A61K39/39 , A61P35/00 , A61K2039/54
摘要: Embodiments of the present invention provide for methods of treating cancer and methods of delivering toll-like receptor (TLR) agonists to solid tumors in the pancreas using a locoregional therapy through the vasculature. In one aspect, the present invention relates to a method of treating pancreatic cancer comprising administering TLR agonists to the pancreas.
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