公开(公告)号：US12201720B2

公开(公告)日：2025-01-21

申请号：US17725677

申请日：2022-04-21

Applicant: Tris Pharma, Inc.

Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

IPC: A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K9/50 ,  A61K31/19 ,  A61K47/50

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provide. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

公开(公告)号：US11337920B2

公开(公告)日：2022-05-24

申请号：US16955392

申请日：2018-12-18

Applicant: Tris Pharma, Inc.

Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

IPC: A61K9/00 ,  A61K31/19 ,  A61K47/58 ,  A61K9/16 ,  A61K9/50

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one GHB drug in a first pulse release which releases in less than about 3 hours; (b) at least one GHB drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent; and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one GHB drug in the stomach for at least about 3 hours.

公开(公告)号：US11666546B2

公开(公告)日：2023-06-06

申请号：US16955389

申请日：2018-12-18

Applicant: Tris Pharma, Inc.

Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

IPC: A61K31/19 ,  A61K9/08 ,  A61K9/00 ,  A61K47/36

CPC classification number: A61K31/19 ,  A61K9/0053 ,  A61K9/08 ,  A61K47/36

Abstract: GHB drug delivery systems comprising a floating interpenetrating network (IPN) are provided. The pharmaceutical compositions contain at least one IPN forming system, at least GHB drug, and at least one gas generating agent, such that upon oral ingestion of the compositions, a floating IPN is formed in situ. These floating IPN provide extended release of the GHB drug entrapped therein for at least about 3 hours.

公开(公告)号：US20220241189A1

公开(公告)日：2022-08-04

申请号：US17725673

申请日：2022-04-21

Applicant: Tris Pharma, Inc.

Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

IPC: A61K9/00 ,  A61K9/16

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.

公开(公告)号：US11337919B2

公开(公告)日：2022-05-24

申请号：US16955377

申请日：2018-12-18

Applicant: Tris Pharma, Inc.

Inventor： Paras Rameshlal Jain ,  Sachin Vasant Chaudhari

IPC: A61K9/00 ,  A61K31/00 ,  A61K47/58 ,  A61K9/16 ,  A61K45/06

Abstract: An orally administrable drug powder composition which forms a gastro-retentive RAFT having at least two trigger pulses is provided. The composition contains, at a minimum, (a) at least one drug in an immediate release pulse release form; (b) at least one drug in a delayed trigger release form; (c) at least one non-toxic gas generating agent and (d) a RAFT system, wherein following oral ingestion, the composition provides a self-assembling gastro-retentive RAFT having entrapped therein, the at least one drug of (a) and (b) and the gas generated in situ by the non-toxic gas generating agent, thereby providing a floating gastro-retentive RAFT having a dual pulse system wherein at least the second pulse is a trigger pulse and which retains the at least one drug in the stomach for at least about 3 hours, provided that the composition does not include a gamma hydroxybutyrate and its salts, hydrates, tautomers, or solvates, or complexes thereof.