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    UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEIN
    1.
    发明申请
    UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEIN 有权

    公开(公告)号：US20220213460A1

    公开(公告)日：2022-07-07

    申请号：US17480166

    申请日：2021-09-21

    申请人： Trustees of Dartmouth College

    发明人： Karl E. Griswold ,  Hongliang Zhao

    IPC分类号： C12N9/52

    摘要： Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.

    UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEIN
    4.
    发明申请
    UNGLYCOSYLATED LYSOSTAPHIN VARIANT PROTEIN 审中-公开
    不溶性胶原蛋白变体蛋白

    公开(公告)号：US20160168556A1

    公开(公告)日：2016-06-16

    申请号：US14907746

    申请日：2014-07-16

    申请人： TRUSTEES OF DARTMOUTH COLLEGE

    发明人： Karl E. Griswold ,  Hongliang Zhao

    IPC分类号： C12N9/52

    CPC分类号： C12N9/52 ,  A61K38/00 ,  C12Y304/24075

    摘要： Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.

    摘要翻译： 提供了非糖基化溶葡萄球菌变体蛋白，核酸分子，载体和宿主细胞，以及在酵母表达系统中产生非糖基化溶葡萄球菌素变体蛋白的方法。 蛋白质在巴斯德毕赤酵母表达系统中产生并且已被证明具有与野生型溶葡萄球菌素相当的活性。 溶葡萄球菌素变体蛋白可用作治疗诸如金黄色葡萄球菌感染等疾病的治疗性蛋白质。

    Unglycosylated lysostaphin variant protein
    5.
    发明授权
    Unglycosylated lysostaphin variant protein 有权

    公开(公告)号：US12049653B2

    公开(公告)日：2024-07-30

    申请号：US17480166

    申请日：2021-09-21

    申请人： Trustees of Dartmouth College

    发明人： Karl E. Griswold ,  Hongliang Zhao

    IPC分类号： C12N9/52 ,  A61K38/00

    CPC分类号： C12N9/52 ,  C12Y304/24075 ,  A61K38/00

    摘要： Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.

    Unglycosylated lysostaphin variant protein
    6.
    发明授权
    Unglycosylated lysostaphin variant protein 有权

    公开(公告)号：US11155801B2

    公开(公告)日：2021-10-26

    申请号：US14907746

    申请日：2014-07-16

    申请人： Trustees of Dartmouth College

    发明人： Karl E. Griswold ,  Hongliang Zhao

    IPC分类号： C12N9/52 ,  A61K38/00

    摘要： Unglycosylated lysostaphin variant protein, nucleic acid molecule, vector and host cell, as well as a method for production of unglycosylated lysostaphin variant protein in a yeast expression system are provided. The proteins are produced in a Pichia pastoris expression system and have been shown to have activity equivalent to wild-type lysostaphin. The lysostaphin variant proteins can be used as therapeutic proteins for treatment of diseases such as Staphylococcus aureus infection.