公开(公告)号：US11382971B2

公开(公告)日：2022-07-12

申请号：US15757893

申请日：2016-09-08

申请人： Tsinghua University

发明人： Yonghui Zhang ,  Yun Xia ,  Yonghua Xie ,  Zhengsen Yu ,  Xiaoying Zhou ,  Xin Li ,  Liping Li ,  Yunyun Yang ,  Kanzhao Gao ,  Ke Wang ,  Wanli Liu ,  Meng Zhao

IPC分类号： A61P37/02 ,  A61K39/39 ,  A61K31/663 ,  A61K39/00

摘要： Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.

公开(公告)号：US20190321465A1

公开(公告)日：2019-10-24

申请号：US15757893

申请日：2016-09-08

申请人： Tsinghua University

发明人： Yonghui Zhang ,  Yun Xia ,  Yonghua Xie ,  Zhengsen Yu ,  Xiaoying Zhou ,  Xin Li ,  Liping Li ,  Yunyun Yang ,  Kanzhao Gao ,  Ke Wang ,  Wanli Liu ,  Meng Zhao

IPC分类号： A61K39/39 ,  A61K31/663 ,  A61P37/02

摘要： Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate to pathway as an adjuvant.

公开(公告)号：US20220387584A1

公开(公告)日：2022-12-08

申请号：US17664134

申请日：2022-05-19

申请人： Tsinghua University

发明人： Yonghui Zhang ,  Yun Xia ,  Yonghua Xie ,  Zhengsen Yu ,  Xiaoying Zhou ,  Xin Li ,  Liping Li ,  Yunyun Yang ,  Kanzhao Gao ,  Ke Wang ,  Wanli Liu ,  Meng Zhao

IPC分类号： A61K39/39 ,  A61P37/02 ,  A61K31/663

摘要： Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjutant.