公开(公告)号：US5659066A

公开(公告)日：1997-08-19

申请号：US618602

申请日：1996-03-20

申请人： Tsugio Murakami ,  Hidetaka Egashira ,  Kengo Okajima ,  Hidetoshi Wakamatsu

发明人： Tsugio Murakami ,  Hidetaka Egashira ,  Kengo Okajima ,  Hidetoshi Wakamatsu

IPC分类号： C07K5/072 ,  C07K5/075 ,  C07K5/06

CPC分类号： C07K5/0613

摘要： Described herein is a method for crystallizing aspartame (APM) by cooling an aqueous solution containing APM without forced convection during part of the crystallization, wherein a clear aqueous APM solution is initially cooled under forced convection and forced convection is interrupted, after crystallization has started but before the concentration of the APM crystals formed in the system reaches 0.5% by weight, until the amount of crystals reaches at least 10%, but not more than 50%, of the target amount, and wherein cooling is interrupted for at least part of the time of said interruption of forced convection at about the same time or shortly thereafter.

摘要翻译： 本文描述的是通过在部分结晶期间冷却含有APM的水溶液而不强制对流来使阿斯巴甜（APM）结晶的方法，其中在强制对流下首先冷却透明水性APM溶液，并且在结晶开始后强制对流被中断， 在系统中形成的APM晶体的浓度达到0.5重量％之前，直到晶体的量达到目标量的至少10％但不超过50％，并且其中冷却至少部分 大约在同一时间或之后不久中断强制对流的时间。