公开(公告)号：US20110275703A1

公开(公告)日：2011-11-10

申请号：US12375363

申请日：2007-07-27

申请人： Tsutomu Sato ,  Kiyofumi Honda ,  Takahiro Kawai ,  Koo Hyeon Ahn

发明人： Tsutomu Sato ,  Kiyofumi Honda ,  Takahiro Kawai ,  Koo Hyeon Ahn

IPC分类号： A61K31/352 ,  A61P3/04 ,  A61K31/381 ,  A61P3/10 ,  C07D493/10 ,  C07D409/14

CPC分类号： C07H19/01

摘要： The present invention provides a compound represented by Formula (II): wherein R1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group; Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d): wherein R2 is a C1-6 alkyl group which may be substituted with one or more halogen atoms, a C1-6 alkoxy group which may be substituted with one or more halogen atoms, a C1-3 alkylthio group, a halogen atom, a C1-3 alkylcarbonyl group or a C2-5 alkynyl group which may be substituted with —OR4; R3 is a hydrogen atom or a C1-3 alkyl group; R4 is a hydrogen atom or a C1-3 alkyl group; provided that Ar is a group represented by Formula (a) when R1 is a fluorine atom, methyl group or an ethynyl group, and that R2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical agent, a pharmaceutical composition and so on comprising the compound.

摘要翻译： 本发明提供由式（II）表示的化合物：其中R1是氯原子，氟原子，甲基或乙炔基; Ar是由下式（a），式（b），式（c）或式（d）表示的基团：其中R 2是可以被一个或多个卤素原子取代的C 1-6烷基，C 1 可以被一个或多个卤素原子取代的C 1-6烷氧基，可以被-OR 4取代的C 1-3烷硫基，卤素原子，C 1-3烷基羰基或C 2-5炔基; R3是氢原子或C1-3烷基; R4是氢原子或C1-3烷基; 条件是当R1为氟原子，甲基或乙炔基时，Ar为式（a）所示的基团，R2为甲氧基，乙氧基，异丙基，丙基，三氟甲基， 三氟甲氧基，2-氟乙基或1-丙炔基，R 1为甲基或其药学上可接受的盐或溶剂化物，药物组合物，药物组合物等。