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    2,5-Di-substituted 4-oxazolealkanoic acids and esters
    1.
    发明授权
    2,5-Di-substituted 4-oxazolealkanoic acids and esters 失效
    2,5-二取代的4-氧杂唑酮酸和酯

    公开(公告)号：US4053478A

    公开(公告)日：1977-10-11

    申请号：US748450

    申请日：1976-12-08

    申请人： Tsutomu Yamanaka ,  Toshihiro Kobayakawa ,  Mitsuhiro Konishi ,  Kuniki Ikeda

    发明人： Tsutomu Yamanaka ,  Toshihiro Kobayakawa ,  Mitsuhiro Konishi ,  Kuniki Ikeda

    IPC分类号： C07D263/42 ,  C07D413/04 ,  A61K31/42 ,  A61K31/44 ,  C07D413/12

    CPC分类号： C07D263/42 ,  Y10S514/822 ,  Y10S514/824

    摘要： 2,5-Di-substituted 4-oxazolealkanoic acids and esters thereof of the formula: ##STR1## WHEREIN M REPRESENTS AN INTEGER OF 1 TO 2; R.sup.1 represents an alkyl group having 1 to 4 carbon atoms; n represents an integer of 1 to 2; R represents a mono- or di-substituted phenyl group (in which the substituents are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, a nitro group, a trifluoromethyl group, a phenyl group, a halogen-substituted phenyl group, a phenoxy group and a halogen-substituted phenoxy group), a pyridyl group, a halogen-substituted pyridyl group, a furyl group, a halogen-substituted furyl group, a thienyl group, a halogen-substituted thienyl group, a naphthyl group or a halogen-substituted naphthyl group; when m represents an integer of 1, Y represents an hydrogen atom, an alkyl group having 1 to 2 carbon atoms, a benzyl group or a pyridylmethyl group; and when m represents an integer of 2, Y represents a trimethylene group. These compounds are useful as drugs for the treatment of arteriosclerosis, thrombosis and hypertension with lipid metabolism disorder.

    2,5-Di-substituted 4-oxazolealkanoic acid and esters
    2.
    发明授权
    2,5-Di-substituted 4-oxazolealkanoic acid and esters 失效
    2,5-二取代的4-恶唑烷酸和酯

    公开(公告)号：US4012412A

    公开(公告)日：1977-03-15

    申请号：US557692

    申请日：1975-03-12

    申请人： Tsutomu Yamanaka ,  Toshihiro Kobayakawa ,  Mitsuhiro Konishi ,  Kuniki Ikeda

    发明人： Tsutomu Yamanaka ,  Toshihiro Kobayakawa ,  Mitsuhiro Konishi ,  Kuniki Ikeda

    IPC分类号： A61K31/421 ,  C07D263/42

    CPC分类号： C07D263/42 ,  Y10S514/822

    摘要： 2,5-Di-substituted 4-oxazolealkanoic acids and esters thereof of the formula: ##STR1## WHEREIN M REPRESENTS AN INTEGER OF 1 TO 2; R.sup.1 represents an alkyl group having 1 to 4 carbon atoms; n represents an integer of 1 to 2; R represents a mono- or di-substituted phenyl group (in which the substituents are selected from the group consisting of a halogen atom, a methyl group, a methoxy group, a nitro group, a trifluoromethyl group, a phenyl group, a halogen-substituted phenyl group, a phenoxy group and a halogen-substituted phenoxy group), a pyridyl group, a halogen-substituted pyridyl group, a furyl group, a halogen-substituted furyl group, a thienyl group, a halogen-substituted thienyl group, a naphthyl group or a halogen-substituted naphthyl group; when m represents an integer of 1, Y represents an hydrogen atom, an alkyl group having 1 to 2 carbon atoms, a benzyl group or a pyridylmethyl group; and when m represents an integer of 2, Y represents a trimethylene group. These compounds are useful as drugs for the treatment of arteriosclerosis, thrombosis and hypertension with lipid metabolism disorder.

    摘要翻译： 2,5-二取代的4-恶唑烷酸及其酯，具有下式：其中M代表1至2的整数; R1表示碳原子数1〜4的烷基。 n表示1〜2的整数， R表示单取代或二取代的苯基（其中取代基选自卤素原子，甲基，甲氧基，硝基，三氟甲基，苯基， 取代苯基，苯氧基和卤素取代的苯氧基），吡啶基，卤素取代的吡啶基，呋喃基，卤素取代的呋喃基，噻吩基，卤素取代的噻吩基， 萘基或卤素取代的萘基; 当m表示1的整数时，Y表示氢原子，碳原子数1〜2的烷基，苄基或吡啶基甲基。 当m表示2的整数时，Y表示三亚甲基。 这些化合物可用作用于治疗动脉硬化，血栓形成和高血压与脂质代谢紊乱的药物。