公开(公告)号：US20220135507A1

公开(公告)日：2022-05-05

申请号：US17087841

申请日：2020-11-03

Applicant: U.S. Department of Energy

Inventor： Cameron Moore ,  Trideep Rajale ,  Karthikeyan K. Ramasamy ,  Andrew Sutton

IPC: C07C29/92

Abstract: The invention relates to a two-way approach to isolate, recover and upgrade 2,3-Butanediol (2,3-BDO) from fermentation broth. A complete separation and recovery process for 2,3-BDO using acetalization and trans-acetalization sequence. Acetalization with butyraldehyde using heterogeneous catalysts, either Amberlyst-15® or Nafion NR50®, efficiently isolates 2,3-BDO as phase-separated protected dioxolane. The approach provides significant process advantages with easy product recovery and high recyclability of the catalyst. Trans-acetalization of dioxolane with methanol (methanolysis) followed by distillation of acetal, yielded very high purity 2,3-BDO with about 90% isolated yield. Alternatively, dioxolane is used in a process direct to methyl ethyl ketone (MEK) as a BDO synthon allowing for recovery of the aldehyde.

公开(公告)号：US11565989B2

公开(公告)日：2023-01-31

申请号：US17087841

申请日：2020-11-03

Applicant: U.S. Department of Energy

Inventor： Cameron Moore ,  Trideep Rajale ,  Karthikeyan K. Ramasamy ,  Andrew Sutton

IPC: C07C29/92 ,  C07C31/20

Abstract: The invention relates to a two-way approach to isolate, recover and upgrade 2,3-Butanediol (2,3-BDO) from fermentation broth. A complete separation and recovery process for 2,3-BDO using acetalization and trans-acetalization sequence. Acetalization with butyraldehyde using heterogeneous catalysts, either Amberlyst-15® or Nafion NR50®, efficiently isolates 2,3-BDO as phase-separated protected dioxolane. The approach provides significant process advantages with easy product recovery and high recyclability of the catalyst. Trans-acetalization of dioxolane with methanol (methanolysis) followed by distillation of acetal, yielded very high purity 2,3-BDO with about 90% isolated yield. Alternatively, dioxolane is used in a process direct to methyl ethyl ketone (MEK) as a BDO synthon allowing for recovery of the aldehyde.