公开(公告)号：US20170275355A1

公开(公告)日：2017-09-28

申请号：US15476279

申请日：2017-03-31

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki ,  Simon Peter Tickle

IPC: C07K16/24 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/244 ,  A61K47/60 ,  A61K2039/505 ,  C07K16/464 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: The invention relates to an antibody molecule having specificity for antigenic determinants of IL-17, therapeutic uses of the antibody molecule and methods for producing said antibody molecule.

公开(公告)号：US20160039929A1

公开(公告)日：2016-02-11

申请号：US14795374

申请日：2015-07-09

Applicant: UCB Biopharma SPRL

Inventor： Richard Evan Gelinas ,  Mitra Choudhury Singhal ,  Yi Zhang ,  Andrew George Popplewell ,  Ralph Adams

IPC: C07K16/24

CPC classification number: A61K39/3955 ,  A61K2039/505 ,  C07K16/248 ,  C07K2316/96 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/11

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of IL-6, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

Abstract translation: 本发明涉及对IL-6的抗原决定簇具有特异性的抗体分子，抗体分子的治疗用途以及产生所述抗体分子的方法。

公开(公告)号：US10308723B2

公开(公告)日：2019-06-04

申请号：US15482260

申请日：2017-04-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki

IPC: A61K39/395 ,  C07K16/46 ,  C07K16/24

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.

公开(公告)号：US20190233530A1

公开(公告)日：2019-08-01

申请号：US16379844

申请日：2019-04-10

Applicant: UCB BIOPHARMA SPRL ,  BIOGEN MA INC.

Inventor： Linda C. Burkly ,  Janine L. Ferrant-Orgettas ,  Ellen A. Garber ,  Yen-Ming Hsu ,  Lihe Su ,  Frederick R. Taylor ,  Ralph Adams ,  Derek Thomas Brown ,  Andrew George Popplewell ,  Martyn Kim Robinson ,  Anthony Shock ,  Kerry Louise Tyson

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2875 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/40 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/71 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

Abstract: This invention provides binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind a CD154 (CD40L) protein. This invention also provides a chimeric, humanized or fully human antibody, antibody derivative or antibody fragment that specifically binds to an epitope to which a humanized Fab fragment comprising a variable heavy chain sequence according to SEQ ID NO: 1 and comprising a variable light chain sequence according to SEQ ID NO: 2 specifically binds. CD154 binding proteins of this invention may elicit reduced effector function relative to a second anti-CD154 antibody. CD154 binding proteins of this invention are useful in diagnostic and therapeutic methods, such as in the treatment and prevention of diseases including those that involve undesirable immune responses that are mediated by CD154-CD40 interactions.

公开(公告)号：US09890219B2

公开(公告)日：2018-02-13

申请号：US14706234

申请日：2015-05-07

Applicant: UCB BIOPHARMA SPRL

Inventor： Ralph Adams ,  Andrew George Popplewell ,  Stephen Edward Rapecki

IPC: A61K39/395 ,  C07K16/46 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  C07K16/244 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/90 ,  C07K2317/92

Abstract: The invention relates to antibody molecules having specificity for antigenic determinants of both IL-17A and IL-17F, therapeutic uses of the antibody molecules and methods for producing said antibody molecules.