公开(公告)号：US20170145114A1

公开(公告)日：2017-05-25

申请号：US15417973

申请日：2017-01-27

Applicant: UCB BIOPHARMA SPRL

Inventor： Andrew George POPPLEWELL ,  Simon Peter TICKLE ,  Heather Margaret LADYMAN

IPC: C07K16/46 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/464 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/3061 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

公开(公告)号：US20210371547A1

公开(公告)日：2021-12-02

申请号：US17151911

申请日：2021-01-19

Applicant: UCB BIOPHARMA SPRL

Inventor： Simon Peter TICKLE ,  Heather Margaret LADYMAN

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

公开(公告)号：US20160326247A1

公开(公告)日：2016-11-10

申请号：US15069078

申请日：2016-03-14

Applicant: UCB BIOPHARMA SPRL

Inventor： Andrew George POPPLEWELL ,  Simon Peter TICKLE ,  Heather Margaret LADYMAN

IPC: C07K16/28

CPC classification number: C07K16/464 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2803 ,  C07K16/2851 ,  C07K16/3061 ,  C07K2317/20 ,  C07K2317/24 ,  C07K2317/40 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92

Abstract: There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human CD22. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a modified CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by cells expressing CD22.

Abstract translation: 公开了含有至少一种衍生自对人CD22具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是修饰的CDR。 进一步公开的是编码抗体分子链，载体，转化的宿主细胞的链DNA序列和抗体分子在治疗由表达CD22的细胞介导的疾病中的用途。