公开(公告)号：US20230374148A1

公开(公告)日：2023-11-23

申请号：US18248651

申请日：2021-10-14

申请人： UCB BIOPHARMA SRL

发明人： Stephen Edward RAPECKI ,  Ralph ADAMS ,  David Paul HUMPHREYS ,  Helen Margaret FINNEY ,  Rosemary Frances BITHELL

IPC分类号： C07K16/28 ,  C07K16/18 ,  A61P35/00 ,  A61P35/02

CPC分类号： C07K16/289 ,  C07K16/18 ,  A61P35/00 ,  A61P35/02 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/24 ,  C07K2317/73 ,  C07K2317/72 ,  C07K2317/55 ,  C07K2317/92 ,  C07K2317/35

摘要： The present invention provides binding molecule or molecules that are able to multimerise CD45 to induce cell death of a cell expressing CD45 without also inducing significant cytokine release. For example, the invention provides antibodies against CD45, wherein the antibodies comprise at least two different paratopes each specific for a different epitope of CD45. The antibodies may be used to cross-link CD45 on the surface of cells. The antibodies may be used in a variety of therapeutic ways including to deplete cells, for example prior to cell transplantation.