公开(公告)号：US20250073179A1

公开(公告)日：2025-03-06

申请号：US18282554

申请日：2022-03-17

Applicant: UCB BIOPHARMA SRL

Inventor： SARAH MARQUETTE ,  CHRISTIAN GRANDFILS ,  JÉRÔME HURLET

IPC: A61K9/70 ,  A61K45/06 ,  A61K47/10 ,  A61K47/59 ,  B33Y80/00

Abstract: The invention relates to the field of pharmaceutical compositions comprising proteins as therapeutic active ingredient. More particularly it is directed to di-block or multi-block copolymers used as excipients, and in particular as stabilizer, in protein-containing dried compositions, filaments obtained from these dried compositions, implantable drug delivery device formed from these filaments and to methods of producing such compositions, filaments and devices.

公开(公告)号：US20240000719A1

公开(公告)日：2024-01-04

申请号：US18039498

申请日：2021-11-29

Applicant: UCB BIOPHARMA SRL

Inventor： SARAH MARQUETTE ,  JONATHAN ELEUTHÈRE MAURICE GOOLE ,  EMERIC CARLIER

IPC: A61K9/70 ,  A61K47/26 ,  A61K9/14 ,  A61K47/10 ,  A61K47/34 ,  A61K47/18 ,  A61K9/19 ,  A61K9/00

CPC classification number: A61K9/70 ,  A61K47/26 ,  A61K9/146 ,  A61K47/10 ,  A61K47/34 ,  A61K47/183 ,  A61K9/19 ,  A61K9/0024 ,  B33Y70/00

Abstract: The invention relates to the field of pharmaceutical compositions comprising proteins as therapeutic agents. More particularly, it is directed to hot melt extrusion-produced antibody-containing filaments, implantable drug delivery devices made from these filaments and to methods of producing such filaments and devices. The hot melt extrusion-produced antibody-containing filaments and the devices obtained from the filaments according to the invention allow the delivery of the antibody over a certain period of time.