专利检索 ap:("UCB BIOPHARMA SRL" OR "BIOGEN MA INC.") AND inv:"Carrie G. Wager" 第 1 页

1.

发明授权
Molecular signatures for use in diagnosis and response to treatment analysis of autoimmune diseases 有权

公开(公告)号：US11142794B2

公开(公告)日：2021-10-12

申请号：US15763890

申请日：2016-10-04

申请人： UCB BIOPHARMA SRL , BIOGEN MA INC.

发明人： Geoffrey Johnston , Carrie G. Wager , Huo Li , Ann Ranger

IPC分类号： C12Q1/68 , C12Q1/6883

摘要： The present invention relates to molecular signatures that can be used to identify patients diagnosed with an autoimmune disease, in particular with systemic lupus erythematosus for treatment with a CD40 or CD40L antagonist such as anti-CD40 antibody, anti-CD40L antibody or a binding fragment thereof. The signatures can also be used to monitor target engagement and response to treatment.