公开(公告)号：US20200048372A1

公开(公告)日：2020-02-13

申请号：US16508967

申请日：2019-07-11

Applicant: UCB PHARMA S.A.

Inventor： Ralph Adams ,  Laura Hancock ,  Sam Philip Heywood

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/24 ,  C07K16/18

Abstract: A multivalent antibody fusion protein which comprises an immunoglobulin moiety, for example a Fab or Fab′ fragment, with a first specificity for an antigen of interest, and further comprises two single domain antibodies (dAb) with specificity for a second antigen of interest, wherein the two single domain antibodies are linked by a disulfide bond. There is also provided particular dual specificity antibody fusion proteins comprising a Fab or Fab′ fragment and one or more single domain antibodies which may be stabilised by a disulfide bond therebetween.