公开(公告)号：US08710054B2

公开(公告)日：2014-04-29

申请号：US13681840

申请日：2012-11-20

Applicant: UCB Pharma, S.A.

Inventor： Rikki Peter Alexander ,  Pavandeep Singh Aujla ,  Karen Viviane Lucile Crepy ,  Anne Marie Foley ,  Richard Jeremy Franklin

IPC: A61K31/535 ,  C07D413/14

CPC classification number: C07D495/04 ,  C07D513/04 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 一系列在二位被取代的吗啉-4-基部分取代的6,7-二氢[1,3]噻唑并[5,4-c]吡啶-4（5H） - 酮衍生物是 因此PI3激酶的选择性抑制剂在医学中是有益的，例如在治疗炎症，自身免疫，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病中。

公开(公告)号：US20130079330A1

公开(公告)日：2013-03-28

申请号：US13681840

申请日：2012-11-20

Applicant: UCB Pharma, S.A.

Inventor： Rikki Peter Alexander ,  Pavandeep Singh Aujla ,  Karen Viviane Lucile Crepy ,  Anne Marie Foley ,  Richard Jeremy Franklin

IPC: C07D495/04

CPC classification number: C07D495/04 ,  C07D513/04 ,  C07D513/12 ,  C07D519/00

Abstract: A series of 6,7-dihydro[1,3]thiazolo[5,4-c]pyridin-4(5H)-one derivatives, which are substituted in the 2-position by a substituted morpholin-4-yl moiety, being selective inhibitors of PI3 kinase enzymes, are accordingly of benefit in medicine, for example in the treatment of inflammatory, autoimmune, cardiovascular, neurodegenerative, metabolic, oncological, nociceptive or ophthalmic conditions.

Abstract translation: 一系列在二位被取代的吗啉-4-基部分取代的6,7-二氢[1,3]噻唑并[5,4-c]吡啶-4（5H） - 酮衍生物是 因此PI3激酶的选择性抑制剂在医学中是有益的，例如在治疗炎症，自身免疫，心血管，神经变性，代谢，肿瘤，伤害性或眼科疾病中。