公开(公告)号：US09700547B2

公开(公告)日：2017-07-11

申请号：US14916152

申请日：2014-09-02

申请人： UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS

发明人： Luiz Augusto Basso ,  Pablo Machado ,  Daiana Renck ,  Diógenes Santiago Santos

IPC分类号： A61K31/4412 ,  A61K31/513 ,  A61K31/4545

CPC分类号： A61K31/4412 ,  A61K31/4545 ,  A61K31/513 ,  A61K2300/00

摘要： The use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme, and the use of the compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein the inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics.

公开(公告)号：US20160193197A1

公开(公告)日：2016-07-07

申请号：US14916152

申请日：2014-09-02

申请人： UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA, MANTENEDORA DA PUCRS

发明人： Luiz Augusto Basso ,  Pablo Machado ,  Daiana Renck ,  Diógenes Santiago Santos

IPC分类号： A61K31/4412 ,  A61K31/4545 ,  A61K31/513

CPC分类号： A61K31/4412 ,  A61K31/4545 ,  A61K31/513 ,  A61K2300/00

摘要： The use of at least one compound of formula I or II or pharmaceutically acceptable salts thereof, for preparing a pharmaceutical composition that acts by inhibiting the phosphorylase uridine enzyme, and the use of the compounds for preparing a pharmaceutical composition that acts by inhibiting the human phosphorylase uridine enzyme, which can be optionally used in combination with at least one antineoplastic, wherein the inhibition increases the effectiveness of antineoplastic and decreases the side effects caused by the administration of antineoplastics.

摘要翻译： 使用至少一种式I或II化合物或其药学上可接受的盐来制备通过抑制磷酸化酶尿苷酶起作用的药物组合物，以及用于制备通过抑制人磷酸化酶起作用的药物组合物的用途 尿苷酶，其可以任选与至少一种抗肿瘤剂组合使用，其中所述抑制增加抗肿瘤药物的有效性并降低由施用抗肿瘤剂引起的副作用。