公开(公告)号：US11008402B2

公开(公告)日：2021-05-18

申请号：US16326864

申请日：2017-09-15

申请人： UNIVERSITÄT STUTTGART

发明人： Roland Kontermann ,  Lisa Schmitt ,  Meike Hutt ,  Oliver Seifert ,  Monilola Olayioye ,  Michael Hust ,  Stefan Dübel ,  Jonas Zantow

IPC分类号： A61K39/00 ,  C07K16/32 ,  C07K16/28 ,  C07K16/30 ,  A61P35/00 ,  A61K39/395

摘要： The invention provides an antigen-binding protein that specifically binds to a conformational epitope formed by domain III & IV of human epidermal growth factor receptor 3 (HER3) and antigen-binding proteins which compete therewith for binding, as well as fusion protein or conjugate comprising these. The invention also provides nucleic acid molecule comprising a sequence encoding said antigen binding proteins, vectors comprising the nucleic acid, and cells and pharmaceuticals comprising the antigen binding protein, the fusion protein, the nucleic acid, or the vector. The invention also provides the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical for use as a medicament. The invention further provides a method of inhibiting tumor growth or treating cancer, comprising administering a therapeutically effective amount of the antigen binding protein, the fusion protein or conjugate, the nucleic acid, the vector, the cell, or the pharmaceutical.