公开(公告)号：US11142558B2

公开(公告)日：2021-10-12

申请号：US16500849

申请日：2018-04-05

Applicant: UNIVERSITÄT STUTTGART

Inventor： Roman Fischer ,  Roland Kontermann ,  Klaus Pfizenmaier ,  Martin Siegemund

IPC: C07K14/525 ,  A61K38/00

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises two or more polymerization domains (PD).

公开(公告)号：US12065472B2

公开(公告)日：2024-08-20

申请号：US17465186

申请日：2021-09-02

Applicant: UNIVERSITÄT STUTTGART

Inventor： Roman Fischer ,  Roland Kontermann ,  Klaus Pfizenmaier ,  Martin Siegemund

IPC: C07K14/525 ,  A61K38/00

CPC classification number: C07K14/525 ,  A61K38/00 ,  C07K2319/30

Abstract: The present invention relates to a tumor necrosis factor receptor (TNFR) binding protein complex comprising 12 or more N protein ligands (PLs) that specifically bind to the extracellular part of the same TNFR. Preferably, the TNFR binding protein complex binds to the extracellular part of TNFR2. Preferably, the TNFR binding protein complex of the present invention further comprises a two or more polymerization domains (PD).