公开(公告)号：US09949984B2

公开(公告)日：2018-04-24

申请号：US15301523

申请日：2015-04-01

Applicant: UNIVERSITÉ LAVAL

Inventor： Yvon Cormier ,  Evelyne Israel-Assayag

IPC: A61K31/435 ,  A61K31/44 ,  A61K31/551 ,  C07D243/08 ,  C07D401/04

CPC classification number: A61K31/551 ,  A61K31/435 ,  A61K31/44 ,  C07D243/08 ,  C07D401/04

Abstract: A method for treating cancer comprising administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1 and R2 are independently alkyl of 1 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms, Xa is CH or N, Ya is hydrogen or a substituent, each of which is independently selected; n is an integer from 1 to 5, J is a counter ion.

公开(公告)号：US10507212B2

公开(公告)日：2019-12-17

申请号：US15921138

申请日：2018-03-14

Applicant: UNIVERSITÉ LAVAL

Inventor： Yvon Cormier ,  Evelyne Israel-Assayag

IPC: A61K31/551 ,  A61K31/435 ,  A61K31/44 ,  C07D243/08 ,  C07D401/04

Abstract: A method for treating cancer including administering to a patient in need thereof an effective amount of a compound having the formula: wherein R1, R2, Ya, Xa, and J− are as defined herein, and may be where R1 and R2 are independently selected from methyl, ethyl, n-propyl, or i-propyl; Xa is N or CH; Ya is hydrogen or independently selected from halogen, cyano, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, heteroaryl of 6 members and aryl; n is 1 or 2; wherein J− is fluoride, chloride, bromide, iodide, acetate, sulfate or sulfonate such as tosylate, mesylate, besylate.