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公开(公告)号：US20240092848A1
公开(公告)日：2024-03-21
申请号：US18482736
申请日：2023-10-06
发明人： Benoit VANHOLLEBEKE
CPC分类号： C07K14/4705 , A61P25/00 , G01N33/5041 , A61K38/00
摘要： Therapeutic agents are capable of activating (GPR)124/RECK/Frizzled/lipoprotein receptor-related protein (LRP)-mediated Wnt signaling. The agents do not activate Frizzled/LRP-mediated Wnt signaling in the absence of RECK and/or GPR124. The agents are particularly useful for the prevention or treatment of neurovascular disorders or central nervous system (CNS) disorders that include neurovascular dysfunction.
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公开(公告)号：US20230399369A1
公开(公告)日：2023-12-14
申请号：US18304018
申请日：2023-04-20
发明人： Benoit VANHOLLEBEKE
CPC分类号： C07K14/4705 , A61P25/00 , G01N33/5041 , A61K38/00
摘要： Therapeutic agents are capable of activating (GPR)124/RECK/Frizzled/lipoprotein receptor-related protein (LRP)-mediated Wnt signaling. The agents do not activate Frizzled/LRP-mediated Wnt signaling in the absence of RECK and/or GPR124. The agents are particularly useful for the prevention or treatment of neurovascular disorders or central nervous system (CNS) disorders that include neurovascular dysfunction.
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公开(公告)号：US20230212240A1
公开(公告)日：2023-07-06
申请号：US17932264
申请日：2022-09-14
发明人： Benoit VANHOLLEBEKE
CPC分类号： C07K14/4705 , A61P25/00 , G01N33/5041 , A61K38/00
摘要： The present application relates to novel therapeutic agents, particularly to agents capable of activating (GPR)124/RECK/Frizzled/lipoprotein receptor-related protein (LRP)-mediated Wnt signaling, wherein said agents do not activate Frizzled/LRP -mediated Wnt signaling in the absence of RECK and/or GPR124. The present agents are particularly useful for the prevention or treatment of neurovascular disorders or central nervous system (CNS) disorders comprising neurovascular dysfunction.
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