公开(公告)号：US20230340100A1

公开(公告)日：2023-10-26

申请号：US18320162

申请日：2023-05-18

申请人： UNIVERSITAT ZURICH

发明人： Burkhard BECHER ,  Sonia TUGUES

IPC分类号： C07K16/24 ,  A61P37/06 ,  C07K16/28 ,  A61P35/02

CPC分类号： C07K16/243 ,  A61P37/06 ,  C07K16/2866 ,  A61P35/02 ,  A61K2039/505

摘要： Described herein is the use of a non-agonist ligand, particularly an antibody, specifically binding to GM-CSF or one of CD116, CD131 and the GM-CSF receptor composed of CD116 and CD131 for use in treatment of leukemia in a patient having undergone allo-HCT or in treatment of other complications arising as a consequence of hematopoietic cell transplantation from an immunologically non-identical donor.