公开(公告)号：US20230226231A1

公开(公告)日：2023-07-20

申请号：US18010498

申请日：2021-06-18

申请人： UNIVERSITE D'AIX MARSEILLE ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  ASSISTANCE PUBLIQUE HÔPITAUX DE MARSEILLE

发明人： BENJAMIN GUILLET ,  AHLEM BOUHLEL ,  ANAÏS MOYON ,  BÉATRICE MARIE FLORENCE LOUIS ,  FRANÇOISE DIGNAT-GEORGE ,  LAURE BALASSE ,  PHILIPPE GARRIGUE ,  SAMANTHA FERNANDEZ

IPC分类号： A61K51/08 ,  A61K49/00 ,  A61P35/00

CPC分类号： A61K51/088 ,  A61K49/0004 ,  A61P35/00

摘要： The invention relates to the field of imaging, diagnostic, internal vectorized radiotherapy and nuclear medicine. Inventors herein describe new products for use for labelling, detecting and/or imaging angiogenesis, vasculogenesis or a tissue or organ expressing the APJ receptor; for use for detecting, measuring, diagnosing, staging and/or monitoring angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; for use for preventing or treating angiogenesis, vasculogenesis, an angiogenesis- and/or vasculogenesis-related disease or disorder, and/or a disease or disorder inducing or modulating the expression of a APJ receptor in a tissue or organ; or for use for evaluating or monitoring the therapeutic effect of an angiogenic or antiangiogenic treatment or of an APJ receptor-targeted treatment. Compositions and kits comprising such products are also herein described as well as uses thereof.