专利检索 ap:("UNIVERSITE D'AIX-MARSEILLE" OR "INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)") AND inv:"KARIM HARHOURI" 第 1 页

1.

发明申请
HUMAN SOLUBLE CD146, PREPARATION AND USES THEREOF 审中-公开

公开(公告)号：US20170218082A1

公开(公告)日：2017-08-03

申请号：US15462952

申请日：2017-03-20

申请人： UNIVERSITE D'AIX-MARSEILLE , INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

发明人： MARCEL BLOT-CHABAUD , KARIM HARHOURI , NATHALIE BARDIN , BENJAMIN GUILLET , FRANCOISE DIGNAT-GEORGE

IPC分类号： C07K16/30

摘要： The present invention relates to compositions and methods for modulating angiogenesis in vivo, ex vivo or in vitro. More particularly, the invention relates to a soluble CD146 protein usable in the context of human therapy, as well as to corresponding antibodies. Particular forms of CD146, herein described, may be used to mobilize, in vivo or ex vivo, both mature and immature endothelial cells, as well as to increase their influence on angiogenesis. The invention also relates to compositions comprising such compounds, particularly pharmaceutical or diagnostic compositions, including kits and the like, as well as methods of therapy or diagnosis using said compounds, compositions and cells.