公开(公告)号：US20160114048A1

公开(公告)日：2016-04-28

申请号：US14891065

申请日：2014-05-14

Applicant: UNIVERSITEIT ANTWERPEN

Inventor： Arnout Everaert ,  Annick Ludwig ,  Dave Van Den Plas ,  Wim Weyenberg

IPC: A61K47/38 ,  A61K38/38 ,  A61K31/352 ,  A61K38/47 ,  A61K9/00 ,  A61K47/26

CPC classification number: A61K47/38 ,  A61K9/0048 ,  A61K31/352 ,  A61K38/38 ,  A61K38/47 ,  A61K47/26 ,  C12Y302/01017

Abstract: The present invention relates to a drug release formulation, in particular a sustained release formulation for ophthalmic applications and a method of preparing same. The method is based on the hydration of a given solid polymeric matrix material under mild conditions, allowing versatility with respect to the drug to be formulated. Both said solid polymeric matrix material as well the API hydrated formulation is an object of the present invention. The thus obtained material is particularly suitable for prolonged and sustained delivery of medication to the eye. Thus in a further aspect, the present invention provides the use of said solid polymeric matrix material as well the API hydrated formulation, in ophthalmic applications.

Abstract translation: 本发明涉及一种药物释放制剂，特别是用于眼科应用的缓释制剂及其制备方法。 该方法基于在温和条件下给定的固体聚合物基质材料的水合，允许配制药物的多功能性。 所述固体聚合物基质材料以及API水合制剂都是本发明的目的。 由此获得的材料特别适合于延长和持续地将药物递送至眼睛。 因此，在另一方面，本发明提供了在眼科应用中所述固体聚合物基质材料以及API水合制剂的用途。