公开(公告)号：US20210236665A1

公开(公告)日：2021-08-05

申请号：US17234323

申请日：2021-04-19

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Jesus Manuel PEREZ ,  Santimukul SANTRA

IPC: A61K51/06 ,  A61P35/00 ,  A61K31/519 ,  A61K49/04 ,  C08G63/688 ,  C08G83/00

Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanoparticles can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapeutic compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.

公开(公告)号：US20200023086A1

公开(公告)日：2020-01-23

申请号：US16317757

申请日：2017-07-14

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Jesus Manuel PEREZ ,  Santimukul SANTRA

IPC: A61K51/06 ,  A61K31/519 ,  A61K49/04 ,  A61P35/00 ,  C08G83/00 ,  C08G63/688

Abstract: Disclosed are compositions comprising polymeric nanoparticles and methods of using the same. The polymeric nanopartides can be conjugated with a targeting ligand that is a substrate for a solid tumor-specific cell protein. The polymeric nanoparticles can also comprises an imaging compound and/or a therapeutic agent encapsulated in the hydrophobic interior of the nanoparticle. A cancer therapeutic composition comprising the nanoparticle is also disclosed. The disclosed nanoparticles can be used to target and deliver imaging and/or therapueitc compounds to cancer cells, thereby identifying and/or treating a solid tumor cell target. Methods for treating cancer, such as lung cancer, using the polymeric nanoparticles are also disclosed.

公开(公告)号：US20190277841A1

公开(公告)日：2019-09-12

申请号：US16358049

申请日：2019-03-19

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Jesus Manuel PEREZ ,  Atul ASATI ,  Santimukul SANTRA ,  Charalambos KAITTANIS ,  Sudip NATH

IPC: G01N33/543 ,  G01N33/94 ,  B82Y15/00 ,  B01J31/26 ,  G01N33/58 ,  G01N33/574

Abstract: Methods, systems, compositions include biocompatible polymer coated nanoceria that function as aqueous redox catalyst with enhanced activity at an acidic to moderately alkaline pH value between 1 and 8. The compositions are used as oxidizing agents for decomposition, decontamination or inactivation of organic contaminants, such as, pesticides and chemical warfare agents. Another use includes nanoceria as targetable nanocatalyst prepared by conjugating various targeting ligands to the nanoparticle coating to form a colorimetric or fluorescent probe in immunoassays and other molecule binding assays that involve the use of a molecule in solution that changes the color of the solution or emits a fluorescent signal, where localization of nanoceria to organs or tissue is assessed by treatment with an oxidation sensitive dye or other detection devices. Versatility and uses of the nanoceria compositions are controlled by pH value, choice of dye substrate and thickness of the polymer coating on the ceria nanoparticles.