公开(公告)号：US20240226168A1

公开(公告)日：2024-07-11

申请号：US18621864

申请日：2024-03-29

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja J. COPIK ,  MD Faqrul Hasan ,  Tayler CROOM-PEREZ

IPC: A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  C07K16/28 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  C07K16/2827 ,  C12N5/0646 ,  A61K2039/505

Abstract: Disclosed herein are engineered NK cells suppressed in the expression of T Cell Immunoreceptor with Ig And ITIM Domains (TIGIT) and uses thereof for treating cancers and infectious diseases.