公开(公告)号：US20230321191A1

公开(公告)日：2023-10-12

申请号：US18118941

申请日：2023-03-08

Applicant: University of Central Florida Research Foundation, Inc.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  C12N5/0783 ,  A61K38/17

CPC classification number: A61K38/20 ,  C12N5/0646 ,  A61K38/17 ,  C12N2501/599 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/50 ,  C12N2500/84

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US10463715B2

公开(公告)日：2019-11-05

申请号：US15489460

申请日：2017-04-17

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  C12N5/0783 ,  A61K38/17

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US20170319659A1

公开(公告)日：2017-11-09

申请号：US15489460

申请日：2017-04-17

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  A61K38/17 ,  C12N5/0783

CPC classification number: A61K38/20 ,  A61K38/17 ,  C12N5/0646 ,  C12N2500/84 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/50 ,  C12N2501/599

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US12280094B2

公开(公告)日：2025-04-22

申请号：US18118941

申请日：2023-03-08

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: C12N5/0783 ,  A61K38/17 ,  A61K38/20 ,  A61K39/00

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US11617781B2

公开(公告)日：2023-04-04

申请号：US16672949

申请日：2019-11-04

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  C12N5/0783 ,  A61K38/17

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US20190117736A1

公开(公告)日：2019-04-25

申请号：US16138095

申请日：2018-09-21

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  C12N5/0783 ,  A61K38/17

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US09623082B2

公开(公告)日：2017-04-18

申请号：US14410787

申请日：2013-06-28

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  A61K38/17 ,  C12N5/0783

CPC classification number: A61K38/20 ,  A61K38/17 ,  C12N5/0646 ,  C12N2500/84 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/50 ,  C12N2501/599

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

公开(公告)号：US20150190471A1

公开(公告)日：2015-07-09

申请号：US14410787

申请日：2013-06-28

Applicant: UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.

Inventor： Alicja Copik ,  Vijay Reddy ,  Jeremiah Oyer

IPC: A61K38/20 ,  A61K38/17

CPC classification number: A61K38/20 ,  A61K38/17 ,  C12N5/0646 ,  C12N2500/84 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/50 ,  C12N2501/599

Abstract: The application provides new compositions and methods for stimulating the production of natural killer (NK) cells in a subject. NK cells can be selectively expanded with a combination of stimulating ligands. Methods and compositions for the administration of stimulatory ligands modified to self-insert into tumor cells, thereby stimulating an increase in the number of NK cells in proximity to a tumor, are also described.

Abstract translation: 该应用提供了用于刺激受试者中天然杀伤（NK）细胞产生的新组合物和方法。 可以用刺激配体的组合选择性地扩增NK细胞。 还描述了用于施用经修饰以自我插入肿瘤细胞的刺激性配体，从而刺激接近肿瘤的NK细胞数量增加的方法和组合物。