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公开(公告)号:US20220071928A1
公开(公告)日:2022-03-10
申请号:US17469827
申请日:2021-09-08
发明人: Otto PHANSTIEL, IV , John CONNOR
IPC分类号: A61K31/132 , A61K31/198 , A61K31/13 , A61K31/155 , A61K31/404 , A61K31/16 , A61K31/675 , A61K31/4706 , A61K31/522 , A61K31/4985 , A61K31/505 , A61K31/513 , A61P31/12
摘要: Disclosed herein are polyamine transport inhibitors (PTI) and methods of use as antivirals. Disclosed PTI compounds are useful as treatments for viral infections or can be used as prophylactic agents that protect high risk individuals from becoming infected by the virus. The disclosed PTI compounds can be used alone or in combination with other agents (or other antivirals) to improve patient outcomes such as DFMO (or Remdesivir).