公开(公告)号：US20210003499A1

公开(公告)日：2021-01-07

申请号：US17023851

申请日：2020-09-17

申请人： UNIVERSITY OF CINCINNATI

发明人： Fred R. Beyette, JR. ,  Geethanga Gayan De Silva

IPC分类号： G01N21/03 ,  G01N21/05 ,  G01N21/62

摘要： A sensor for isolating, identifying, and quantifying one or more analytes in a sample is provided, the sensor having a metal substrate base and a polymer waveguide disposed on the metal substrate base, the polymer waveguide including an optical channel and a polymer disposed in the optical channel; wherein the polymer waveguide optically couples a first and a second fiber optic cable. Also provided herein are methods of using the sensor for isolating, identifying, and quantifying one or more analytes in a sample, the method including contacting the polymer waveguide with a sample, sequentially heating the sensor to a plurality of temperature thresholds, obtaining an optical output at each temperature threshold, and analyzing differences in sequentially-obtained optical outputs in order to identify and determine concentrations of individual analytes of interest in the sample.