公开(公告)号：US20140249406A1

公开(公告)日：2014-09-04

申请号：US14072270

申请日：2013-11-05

申请人： UNIVERSITY OF IOWA RESEARCH FOUNDATION

发明人： Ryan Flynn ,  Yusung Kim ,  Xing Li ,  Kee-Ho Yuen

IPC分类号： A61N5/10

CPC分类号： A61N5/1001 ,  A61N5/1014 ,  A61N2005/1012 ,  A61N2005/1096

摘要： Compensator-based brachytherapy (CBT) for treatment of cancerous tumors or other pathologic tissues. CBT permits, in one aspect, increased dosage conformity for non-radially symmetric tumors by utilizing a device that can shield radiation emanated from an electronic brachytherapy (BT) source or non-electronic BT source. The device can comprise, in one aspect, a radiation compensator having a treated surface that comprises a position-dependent thickness based at least on a radiation therapy plan specific to a patient and geometry of a patient region to be treated. In an additional or alternative aspect, the device can comprise a source of radiation movably inserted into an enclosure coupled to the radiation compensator. As part of CBT, in one implementation, the radiation source can reside at a plurality of locations within the radiator compensator during a respective plurality of dwell times based on the radiation therapy plan.

摘要翻译： 用于治疗癌性肿瘤或其他病理组织的基于补偿剂的近距离放射治疗（CBT）。 CBT允许在一个方面通过利用可以屏蔽从电子近距离放射治疗（BT）源或非电子BT源发出的辐射的装置来增加非径向对称肿瘤的剂量一致性。 在一个方面，该装置可以包括具有经处理的表面的辐射补偿器，该处理的表面至少基于患者特有的放射治疗计划和待治疗的患者区域的几何形状包括位置依赖性厚度。 在附加或替代方面，该装置可以包括可移动地插入耦合到辐射补偿器的外壳中的辐射源。 作为CBT的一部分，在一个实施方案中，辐射源可以在基于辐射治疗计划的相应的多个停留时间期间驻留在辐射器补偿器内的多个位置处。