公开(公告)号：US11439700B2

公开(公告)日：2022-09-13

申请号：US17053544

申请日：2019-05-03

Applicant: UNIVERSITY OF KANSAS

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/104 ,  A61K39/118 ,  A61K39/02

Abstract: Disclosed are methods and compositions related to polypeptides comprising a fusion of the needle tip protein and translocator protein of a type III secretion apparatus (T3SA) from a type III secretion system (T3SS) of a Gram negative bacteria. Disclosed herein are fusion polypeptides comprising a fusion of a needle tip protein, such as, Bsp22, LcrV, BipD, PcrV, CT053, or CT668, or anantigenic fragment thereof; and a translocator protein, such as, BopB, YopB, BipB, PopB, CopB, or CopB2, or anantigenic fragment thereof from a Type III secretion system (T3SS) of a Gram negative bacteria, such as, Bordetella, Burkholderia, Chlamydia, Pseudomonas, Vibrio, or Yersinia.

公开(公告)号：US10548962B2

公开(公告)日：2020-02-04

申请号：US15950735

申请日：2018-04-11

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: C07K14/255 ,  A61K39/112 ,  A61K39/00

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US11464843B2

公开(公告)日：2022-10-11

申请号：US16752802

申请日：2020-01-27

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: C07K14/255 ,  A61K39/112 ,  A61K39/00

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US20180228883A1

公开(公告)日：2018-08-16

申请号：US15950735

申请日：2018-04-11

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/112

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US09950053B2

公开(公告)日：2018-04-24

申请号：US15013454

申请日：2016-02-02

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: C07K14/255 ,  A61K39/112 ,  A61K39/00

CPC classification number: A61K39/0275 ,  A61K2039/64 ,  C07K14/255 ,  C07K2319/40 ,  Y02A50/482 ,  Y02A50/484

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US20200306355A1

公开(公告)日：2020-10-01

申请号：US16752802

申请日：2020-01-27

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/112

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US20160220655A1

公开(公告)日：2016-08-04

申请号：US15013454

申请日：2016-02-02

Applicant: The Board of Regents for Oklahoma State University ,  University of Kansas

Inventor： Wendy L. Picking ,  William D. Picking

IPC: A61K39/112 ,  C07K14/255

CPC classification number: A61K39/0275 ,  A61K2039/64 ,  C07K14/255 ,  C07K2319/40 ,  Y02A50/482 ,  Y02A50/484

Abstract: Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

Abstract translation: 本文所述的抗原分子和组合物可防止伤寒和非伤寒沙门氏菌血清型的感染。 免疫方法包括使用抗原分子。