公开(公告)号：US20200032346A1

公开(公告)日：2020-01-30

申请号：US16427185

申请日：2019-05-30

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Jianhua LUO ,  Zhanghui CHEN ,  Yanping YU ,  George MICHALOPOULOS ,  Joel B. NELSON

IPC: C12Q1/6886 ,  A61K31/5377 ,  A61K31/4545 ,  A61P35/00 ,  C12N15/113 ,  A61N7/00

Abstract: The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.

公开(公告)号：US20240404707A1

公开(公告)日：2024-12-05

申请号：US18688105

申请日：2022-09-02

Applicant: UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Jianhua LUO ,  Aatur Dilip SINGHI ,  Baoguo REN ,  Chien-Cheng TSENG ,  George MICHALOPOULOS ,  Michael A. NALESNIK ,  Michelle A. WOOD-TRAGESER ,  Shuchang LIU ,  Yanping YU

IPC: G16H50/30 ,  G16B25/10 ,  G16B40/20 ,  G16H50/20

Abstract: Described herein are prediction models based on the transcriptomic, exomic, and/or radiological analyses on tissue samples to predict the likelihood of the original cancer (such as Hepatocellular carcinoma (HCC)) recurrence into the liver transplant. An example computer implemented method for predicting the likelihood of liver cancer recurrence 5 into a liver transplant includes receiving gene expression data related to a liver tissue sample for a subject having a liver cancer, inputting the gene expression data into a trained machine learning model, and predicting, using the trained machine learning model, a risk of recurrence of the liver cancer in the subject after liver transplantation.

公开(公告)号：US20220290257A1

公开(公告)日：2022-09-15

申请号：US17751152

申请日：2022-05-23

Applicant: UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

Inventor： Jianhua LUO ,  Zhanghui CHEN ,  Yanping YU ,  George MICHALOPOULOS ,  Joel B. NELSON

IPC: C12Q1/6886 ,  A61P35/00 ,  A61K31/4545 ,  A61K31/5377 ,  A61N7/00 ,  C12N15/113

Abstract: The present invention relates to methods of treating cancer patients carrying one or more specific fusion genes. It is based, at least in part, on the discovery that the protein encoded by the MAN2A1-FER fusion gene exhibits kinase activity and the use of tyrosine kinase inhibitors targeting MAN2A1-FER in a cancer other than prostate, for example hepatocellular cancer, led to dramatic improvement of survival of animals xenografted with the cancer.