公开(公告)号：US11439655B2

公开(公告)日：2022-09-13

申请号：US16122087

申请日：2018-09-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchi Moghadam

IPC: A61K31/7048 ,  A61K36/185 ,  A61P17/02 ,  A61L27/54 ,  A61L27/60 ,  A61K31/216 ,  A61K9/48 ,  A61K9/06 ,  A61L15/44 ,  A61L17/00

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of at least one of a flavonoid and a chlorogenic acid that are natural extracts of Parrotia persica, or their derivatives, analogues, or homologs. Compounds based upon these natural extracts have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.