公开(公告)号：US10478527B2

公开(公告)日：2019-11-19

申请号：US15757475

申请日：2016-09-05

申请人： UNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG

发明人： Viness Pillay ,  Yahya Essop Choonara ,  Pradeep Kumar ,  Lisa Claire Du Toit ,  Poornima Ramburrun

IPC分类号： A61L27/48 ,  A61L27/16 ,  A61L27/20 ,  A61L27/52 ,  A61L27/54 ,  A61L27/58 ,  A61L27/56

摘要： This invention relates to biodegradable implants comprising a hydrogel carrier matrix having dispersed therein a multitude of particles, wherein each of the multitude of particles and/or the hydrogel carrier matrix includes an active pharmaceutical ingredient (API) for the treatment of transected peripheral nerve injuries. Each of the multitude of particles and/or the hydrogel carrier matrix includes pristine polymer particles, preferably the pristine polymer particles may be polymethylmethacrylate polymers and derivatives thereof, preferably poly(methacrylic-co-methyl methacrylate) (PMMA). The spheroidal particles may each be formed from an outer shell including a chitosan (CHT) poly(methacrylic-co-methyl methacrylate) (PMMA) polyelectrolyte complex (CHT-PMMA-PEC) and an inner core including crosslinked chitosan having dispersed therein PMMA nanoparticles.