公开(公告)号：US11246477B2

公开(公告)日：2022-02-15

申请号：US16289555

申请日：2019-02-28

Applicant: POSTECH ACADEMY-INDUSTRY FOUNDATION ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  OSONG MEDICAL INNOVATION FOUNDATION

Inventor： Seong Han Kim ,  Seunghun Lee ,  Hoon Cheol Jang ,  Bumju Kim ,  Viet Hoan Le ,  Wonyeong Park ,  Ki Hean Kim ,  Seung Jae Myung ,  Seungrag Lee

IPC: A61B1/04 ,  A61B5/00 ,  A61K31/496

Abstract: A fluorescence endoscopic method for visualization of colorectal tissue using a fluoroquinolone antibiotic and a method for diagnosis of lesions of colorectal tissue using the same. The fluorescence endoscopic method for visualization of colorectal tissue includes staining goblet cells of the colorectal tissue with moxifloxacin, which is a fluoroquinolone antibiotic, and exciting the stained goblet cells with single photons in the near UV region or in the visible region, followed by fluorescence endoscopic photographing of the goblet cells, thereby enabling acquisition of morphological information on living tissue without damage to or destruction of the colorectal tissue, while allowing diagnosis of lesions of the colon based on the morphological information on living tissue such as information on the distribution of the goblet cells. Specifically, the fluorescence endoscopic method includes: a colorectal tissue staining step in which the crypt of the colorectal tissue is stained with a fluoroquinolone antibiotic; an image pickup unit insertion step in which an image pickup unit is inserted into the colon; a light irradiation step in which the colorectal tissue is irradiated with excitation light from a light source of the image pickup unit; a colorectal tissue photographing step in which the colorectal tissue is photographed using a photographing device of the image pickup unit through the fluoroquinolone antibiotic fluorescence-excited by light in the light irradiation step, wherein, in the colorectal tissue staining step, goblet cells of the crypt are stained with the fluoroquinolone antibiotic; in the light irradiation step, the light source emits single photons as excitation light inducing fluorescence of the fluoroquinolone antibiotic, the excitation light from the light source having a wavelength band within the near UV and visible regions; and, in the image pickup unit insertion step, the image pickup unit is a general fluorescence endoscope or a confocal endoscopic microscope.

公开(公告)号：US10750965B2

公开(公告)日：2020-08-25

申请号：US15310793

申请日：2015-03-20

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Se Gyeong Joo ,  Kee Wook Jung ,  Seung Jae Myung ,  Hwoon Yong Jung

IPC: A61B5/03 ,  A61B5/00 ,  A61B5/22 ,  A61B5/053

Abstract: A method for detecting disease using a manometry includes obtaining pressure values from each of the plurality of pressure sensors during a pre-set time, obtaining a three-dimensional pressure distribution showing the changes in the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section, and calculating the volume integral value of the interest location which is predetermined in accordance with the disease, in the three-dimensional pressure distribution.

公开(公告)号：US20190302116A1

公开(公告)日：2019-10-03

申请号：US16304103

申请日：2017-03-17

Applicant: UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION ,  THE ASAN FOUNDATION

Inventor： Hun Sik Kim ,  Seung Jae Myung ,  Song Cheol Kim

IPC: G01N33/569

Abstract: Provided are a method of testing NK cell activity, including: specifically stimulating at least two distinguishable factors on NK cells in a sample; measuring a synergistic activation level of the NK cells; and comparing the synergistic activation level of the NK cells with that of normal NK cells, and a composition for testing NK cell activity. In addition, the present disclosure relates to a kit for diagnosing an NK cell synergistic activity-associated disease, the kit including the composition.