公开(公告)号：US20250026791A1

公开(公告)日：2025-01-23

申请号：US18571941

申请日：2022-06-16

Applicant: UNIVERSITY OF YAMANASHI

Inventor： Takashi KAWAKAMI

IPC: C07K7/54 ,  A61K38/00 ,  C12N15/11

Abstract: A conventional art had the problems that a mixture of a plurality of cyclic peptides can be formed and the cyclization of a peptide does not spontaneously proceed. The present invention provides a peptide compound having a cyclic portion, wherein the cyclic portion has a benzoic acid derivative linker cyclized by an aromatic nucleophilic substitution reaction and a peptide backbone, the peptide backbone has a residue with a thiol group, and the benzoic acid derivative linker is bonded to the peptide backbone via an N-terminal amino acid residue of the peptide backbone and the residue with a thiol group.