专利检索 ap:("USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I." OR "MASARYKOVA UNIVERZITA" OR "FAKULTNI NEMOCNICE U SV. ANNY V BRNE") AND inv:"Lukas BALEK" 第 1 页

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发明申请
NANODIAMONDS AS ARTIFICIAL PROTEINS FOR REGULATION OF A CELL SIGNALLING SYSTEM 有权

公开(公告)号：US20210015856A1

公开(公告)日：2021-01-21

申请号：US16981578

申请日：2019-03-26

申请人： USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I. , MASARYKOVA UNIVERZITA , FAKULTNI NEMOCNICE U SV. ANNY V BRNE

发明人： Petr CIGLER , Lukas BALEK , Jan HAVLIK , Pavel KREJCI , Lukas TRANTIREK , Silvie TRANTIRKOVA

IPC分类号： A61K33/44 , A61K9/14 , A61K45/06 , C07K14/50

摘要： Nanodiamonds having a positive ξ-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ξ-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.