公开(公告)号：US20240120025A1

公开(公告)日：2024-04-11

申请号：US18362754

申请日：2023-07-31

申请人： Ultima Genomics, Inc.

发明人： Yoav ETZIONI ,  Simchon FAIGLER ,  Gilad ALMOGY ,  Mark PRATT ,  Florian OBERSTRASS

IPC分类号： G16B20/20 ,  C12Q1/6874 ,  G06F17/00 ,  G16B20/00 ,  G16B30/00 ,  G16B30/10

CPC分类号： G16B20/20 ,  C12Q1/6874 ,  G06F17/00 ,  G16B20/00 ,  G16B30/00 ,  G16B30/10 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2021/6439

摘要： Methods for detecting a short genetic variant in a test sample are described herein. In some exemplary methods, the short genetic variant is called using one or match scores, which are determined using one or more sequencing data sets obtained from a test nucleic acid molecule, wherein the test sequencing data sets are determined by sequencing the test nucleic acid molecule using non-terminating nucleotides provided in separate nucleotide flows according to a flow-cycle order. Also described herein are methods of sequencing a test nucleic acid molecule using two or more different flow-cycle orders and/or extended flow cycle orders having five or more nucleotide flows per flow cycle.

公开(公告)号：US20240257906A1

公开(公告)日：2024-08-01

申请号：US18617448

申请日：2024-03-26

申请人： Ultima Genomics, Inc.

发明人： Yoav ETZIONI ,  Simchon FAIGLER ,  Gilad ALMOGY ,  Mark PRATT ,  Florian OBERSTRASS ,  Omer BARAD

IPC分类号： G16B20/20 ,  C12Q1/6874 ,  G06F17/00 ,  G16B20/00 ,  G16B30/00 ,  G16B30/10 ,  G01N21/64

CPC分类号： G16B20/20 ,  C12Q1/6874 ,  G06F17/00 ,  G16B20/00 ,  G16B30/00 ,  G16B30/10 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2021/6439

摘要： Methods for detecting a short genetic variant in a test sample are described herein. In some exemplary methods, the short genetic variant is called using one or match scores, which are determined using one or more sequencing data sets obtained from a test nucleic acid molecule, wherein the test sequencing data sets are determined by sequencing the test nucleic acid molecule using non-terminating nucleotides provided in separate nucleotide flows according to a flow-cycle order. Also described herein are methods of sequencing a test nucleic acid molecule using two or more different flow-cycle orders and/or extended flow cycle orders having five or more nucleotide flows per flow cycle.

公开(公告)号：US20200372971A1

公开(公告)日：2020-11-26

申请号：US16864981

申请日：2020-05-01

申请人： Ultima Genomics, Inc.

发明人： Yoav ETZIONI ,  Simchon FAIGLER ,  Gilad ALMOGY ,  Mark PRATT ,  Florian OBERSTRASS

IPC分类号： G16B20/20 ,  C12Q1/6874 ,  G16B30/10

摘要： Methods for detecting a short genetic variant in a test sample are described herein. In some exemplary methods, the short genetic variant is called using one or match scores, which are determined using one or more sequencing data sets obtained from a test nucleic acid molecule, wherein the test sequencing data sets are determined by sequencing the test nucleic acid molecule using non-terminating nucleotides provided in separate nucleotide flows according to a flow-cycle order. Also described herein are methods of sequencing a test nucleic acid molecule using two or more different flow-cycle orders and/or extended flow cycle orders having five or more nucleotide flows per flow cycle.