公开(公告)号：US20210122771A1

公开(公告)日：2021-04-29

申请号：US17255963

申请日：2019-06-28

Applicant: The Regents of the University of California ,  UNIVERSITÄT DUISBURG-ESSEN ,  UNIVERSITÄT ULM

Inventor： Gal Bitan ,  Thomas Schrader ,  Jan Münch ,  Christian Heid ,  Andrea Sowislok ,  Annika Röcker ,  Danielle Bouquio ,  Ravinder Malik

IPC: C07F9/12 ,  A61P25/28 ,  A61P31/18 ,  A61P31/14

Abstract: In various embodiments new molecular tweezers compounds are provided. The compounds described herein (e.g., molecular tweezers) are believed to be useful for inhibiting protein aggregation (or disaggregating aggregated proteins). In certain embodiments the compounds described herein (e.g., molecular tweezers) are believed to be useful in the treatment of pathologies characterized by protein aggregation (e.g., amyloidopathies), and/or in the treatment of brain or spinal cord damage associated with acute trauma, stroke, and the like, and/or in the treatment of lysosomal storage diseases, and/or in the treatment of lipofuscin-related disorders, and in various viral infections.

公开(公告)号：US20240190918A1

公开(公告)日：2024-06-13

申请号：US18553732

申请日：2022-03-29

Applicant: Universität Ulm

Inventor： Jan Münch ,  Desiree Schütz ,  Lena Rauch

IPC: C07K7/06 ,  A61K38/00 ,  A61K48/00

CPC classification number: C07K7/06 ,  A61K48/0025 ,  A61K38/00

Abstract: The present invention relates to a fibril peptide consisting of a sequence of from 8 to 20 amino acids and wherein said fibril peptide comprises the amino acid sequence RTIFIISM or a sequence at least 75% identical thereto. The present invention further relates to a method of delivering a cargo comprised in a particle into a host cell, comprising a) contacting said host cell with said particle and with a fibril peptide according to any one of claims 1 to 8; and, thereby b) delivering said cargo into said host cell; and to uses, kits, and devices related thereto.