公开(公告)号：US20040266735A1

公开(公告)日：2004-12-30

申请号：US10887895

申请日：2004-07-12

申请人： Universite Paris 13

发明人： Marc Lecouvey ,  Yves Leroux ,  Michel Kraemer ,  Michel Crepin ,  Driss El Manouni ,  Malika Louriki

IPC分类号： A61K031/675 ,  A61K031/66 ,  C07F009/28

CPC分类号： C07F9/386 ,  C07F9/404 ,  C07F9/405 ,  C07F9/409

摘要： The present invention relates to derivatives of 1-hydroxymethylene-1,1-bisphosphonic acid, the pharmaceutical compositions comprising them, and their application in therapeutics, particularly for the treatment of cancerous tumors. It is also directed to a methods of preparation of such derivatives.