公开(公告)号：US11406631B2

公开(公告)日：2022-08-09

申请号：US17045049

申请日：2019-04-03

申请人： Universite de Bretagne Occidentale ,  Centre Hospitalier Regional Universitaire de Brest ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut Curie ,  Université de Paris ,  Univ Paris XIII Paris-Nord Villetaneuse ,  Universite Paris-Saclay

发明人： Marc Blondel ,  Alicia Quillevere ,  Cécile Voisset ,  Maria José Lista ,  Robin Fahraeus ,  Chrysoula Daskalogianni ,  Rodrigo Prado-Martins ,  Marie-Paule Teulade-Fichou ,  Anton Granzhan ,  Claire Beauvineau ,  Oksana Reznichenko

IPC分类号： A61K31/4709 ,  A61P31/20 ,  A61P35/00 ,  A61K9/00 ,  A61K31/444 ,  A61K31/4745 ,  A61K31/506 ,  A61K45/06 ,  C07D401/14 ,  C07D471/04

摘要： The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Y1 and Z1 are independently CH or NRc+, provided that al least one of Y1 and Z1 is NRc+ and at least one of Y1 and Z1 is CH, and Ra, Rb, Rc, X2− and L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.

公开(公告)号：US20210161887A1

公开(公告)日：2021-06-03

申请号：US17045049

申请日：2019-04-03

申请人： Universite de Bretagne Occidentale ,  Centre Hospitalier Regional Universitaire de Brest ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Institut Curie ,  Université de Paris ,  Univ Paris XIII Paris-Nord Villetaneuse ,  Universite Paris-Saclay

发明人： Marc Blondel ,  Alicia Quillevere ,  Cécile Voisset ,  Maria José Lista ,  Robin Fahraeus ,  Chrysoula Daskalogianni ,  Rodrigo Prado-Martins ,  Marie-Paule Teulade-Fichou ,  Anton Granzhan ,  Claire Beauvineau ,  Oksana Reznichenko

IPC分类号： A61K31/4709 ,  A61K45/06 ,  A61K9/00 ,  C07D401/14 ,  C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61K31/4745 ,  A61P31/20 ,  A61P35/00

摘要： The present invention relates to novel bis-hydrazone derivatives of formula (I): wherein Ar1 and Ar2 may be identical or different and are each independently selected from the group consisting of groups of formula (II) and (III): Y1 and Z1 are independently CH or NRc+, provided that al least one of Y1 and Z1 is NRc+ and at least one of Y1 and Z1 is CH, and Ra, Rb, Rc, X2− and L as defined in the claims, or a hydrate or a solvate thereof. Compositions and kits comprising same are also described. Said bis-hydrazone derivatives of formula (I), compositions and kits are useful as drugs, in particular for treating or preventing cancers associated with the Epstein-Barr Virus.