公开(公告)号：US20220023320A1

公开(公告)日：2022-01-27

申请号：US17495447

申请日：2021-10-06

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P27/04 ,  A61P25/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

公开(公告)号：US20190175629A1

公开(公告)日：2019-06-13

申请号：US16301240

申请日：2017-05-18

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P25/04 ,  A61P27/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

公开(公告)号：US11638712B2

公开(公告)日：2023-05-02

申请号：US17495447

申请日：2021-10-06

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P27/04 ,  A61P25/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.

公开(公告)号：US11166967B2

公开(公告)日：2021-11-09

申请号：US16301240

申请日：2017-05-18

Applicant: Universiteit Antwerpen

Inventor： Koen Augustyns ,  Jurgen Joossens ,  Pieter Van Der Veken ,  Paul Cos ,  Cedric Joossen ,  Benedicte Yvonne De Winter ,  Hannah Ceuleers ,  Hanne Van Spaendonk

IPC: A61K31/688 ,  A61P27/04 ,  A61P25/04

Abstract: The present invention relates to compounds for use in the prevention and/or treatment of PAR-related diseases, such as for example: pain and ocular disorders. More in particular, the present invention provides bis(acetamidophenyl) guanidinophenylethylphosphonates for use in the prevention and/or treatment of pancreatitis-related pain, IBS (irritable bowel syndrome), IBD (inflammatory bowel disease), dry eye disease and conjunctivitis sicca. These inhibitors were found to have a different inhibitory profile compared to diphenyl guanidinophenylethylphosphonates leading to a more pronounced effect on these conditions.