公开(公告)号：US10738002B2

公开(公告)日：2020-08-11

申请号：US16463544

申请日：2017-11-24

申请人： Universiteit Antwerpen ,  Universitair Ziekenhuis Antwerpen

发明人： Koen Augustyns ,  Matthias Cleenewerck ,  Guido R. Y. De Meyer ,  Jurgen Joossens ,  Ammar Kurdi ,  Pieter Van Der Veken ,  Christel Vangestel ,  Sigrid Stroobants ,  Wim Martinet

IPC分类号： C07C235/82 ,  C07C62/38 ,  C07C69/757 ,  A61P35/00

摘要： The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer. Halogenated benzotropolones described here are of formula

公开(公告)号：US20190284130A1

公开(公告)日：2019-09-19

申请号：US16463544

申请日：2017-11-24

申请人： Universiteit Antwerpen ,  Universitair Ziekenhuis Antwerpen

发明人： Koen Augustyns ,  Matthias Cleenewerck ,  Guido R.Y. De Meyer ,  Jurgen Joossens ,  Ammar Kurdi ,  Pieter Van Der Veken ,  Christel Vangestel ,  Sigrid Stroobants ,  Wim Martinet

IPC分类号： C07C235/82 ,  C07C69/757 ,  C07C62/38

摘要： The present invention relates to compounds having a benzotropolone core, and compositions containing said compounds acting as ATG4B inhibitors, thereby inhibiting autophagy. Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine, in particular for the treatment of cell proliferative disorders, such as cancer.