公开(公告)号：US20230087609A1

公开(公告)日：2023-03-23

申请号：US17797448

申请日：2021-02-18

申请人： Universiteit Maastricht ,  Academisch Ziekenhuis Maastricht

发明人： Harald Horst Heinz Wilhelm Schmidt ,  Mahmoud Hassan Mahmoud Elbatrik ,  Thao-Vi Dao ,  Ana Isabel Casas Guijarro ,  Theodora Saridaki ,  Alexandra Petraina

IPC分类号： A61K31/506 ,  A61K31/137 ,  A61K31/197 ,  A61K31/416 ,  A61K31/427 ,  A61K31/4439 ,  A61K31/5377 ,  A61K45/06 ,  A61P9/00

摘要： The invention relates to a pharmaceutical composition comprising one or more stimulators of soluble guanylate cyclase (sGC), or a combination of at least one stimulator of sGC and at least one activator of sGC, for use in a method of treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3′,5′-guanosine monophosphate in the patient to be treated. The invention also relates to a therapeutic combination comprising a first unit dose comprising an sGC stimulator and a second unit dose comprising an sGC activator. The invention also relates to a therapeutic combination comprising a first unit dose comprising a first sGC stimulator and a second unit dose comprising a second sGC stimulator, for use in a method for the treatment of a disease and/or a disorder that is/are associated with a deficiency of cyclic 3′,5′-guanosine monophosphate in the patient to be treated. Furthermore, the invention relates to a kit comprising a pharmaceutical composition comprising one or more stimulators of sGC; a pharmaceutical composition comprising one or more stimulators of sGC and one or more activators of sGC; a therapeutic combination comprising a first unit dose comprising a first sGC stimulator and a second unit dose comprising a second sGC stimulator; or to a therapeutic combination comprising a first unit dose comprising an sGC stimulator and a second unit dose comprising an sGC activator.