公开(公告)号：US20230100722A1

公开(公告)日：2023-03-30

申请号：US17794003

申请日：2020-12-07

Applicant: University of Cincinnati

Inventor： Joel Andersen

IPC: C07D295/06 ,  C07C201/12 ,  C07C319/14

Abstract: The present invention involves a mechanochemical process in which at least two reactants are mixed without an additional solvent to produce an SNAr reaction product. In one embodiment, the mixing is achieved using a twin-screw extruder. In another embodiment, the mixing is achieved using dry mixing equipment. In one embodiment, the dry mixing equipment is selected from the group consisting of batch Paddle Mills, continuous Paddle Mills, V-Blenders, Twin Cone Blenders and Ribbon Blenders. In another embodiment, the mixing is achieved using a Fluidized Bed reactor.