公开(公告)号：US20190218264A1

公开(公告)日：2019-07-18

申请号：US16339585

申请日：2017-10-04

Applicant: University of Florida Research Foundation, Inc.

Inventor： GREGORY HUDALLA ,  SABRINA FREEMAN ,  ANTONIETTA RESTUCCIA ,  MARGARET FETTIS ,  EVELYN R. BRACHO-SANCHEZ ,  SHAHEEN FARHADI ,  BENJAMIN G. KESELOWSKY

IPC: C07K14/47 ,  C12N9/02

CPC classification number: C07K14/4726 ,  A61K38/00 ,  C07K14/00 ,  C07K2319/33 ,  C07K2319/73 ,  C12N9/0069 ,  C12N15/00 ,  C12Y113/11052 ,  C12Y113/12007

Abstract: Provided herein are targeted effector fusion proteins, complexes thereof, and uses thereof. The targeted effector fusion proteins can include an effector protein that can be linked to a targeting moiety. Monomer targeted effector fusion proteins can form homogeneous or heterogeneous complexes. The targeted effector fusion proteins and complexes thereof can be formulated as pharmaceutical formulations. The targeted effector fusion proteins, complexes thereof, and formulations thereof can be administered to a subject in need thereof.