公开(公告)号：US12163117B2

公开(公告)日：2024-12-10

申请号：US17423303

申请日：2020-01-10

Applicant: University of Florida Research Foundation, Inc.

Inventor： Josephine Allen ,  Bryan D. James

IPC: C12M1/42 ,  C12M1/00 ,  C12M1/12

Abstract: Described herein are bioreactor chambers and systems thereof. In an embodiment, a single-plate symmetrical bioreactor chamber is described, comprising: a flow channel extending along a first axis, wherein the flow channel comprises an inlet and an outlet at opposing ends of 5 the flow channel; a pair of struts on opposing ends of a second axis, wherein the second axis is substantially perpendicular to the first axis, wherein each strut of the pair of struts are placed on opposing sides of the flow channel, wherein the struts are configured to be coupled to a bidirectional linear actuator and configured to provide a strain perpendicular to a fluid flow through the flow channel, wherein the strain does not laterally displace cells present in the flow channel.