公开(公告)号：US20170356009A1

公开(公告)日：2017-12-14

申请号：US15526952

申请日：2015-11-21

Applicant: University of Florida Research Foundation, Inc.

Inventor： Yuan Lu ,  Chen Ling ,  Arun Srivastava

IPC: C12N15/86

CPC classification number: C12N15/86 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2830/002

Abstract: Provided herein are recombinant adeno-associated virus (rAAV) nucleic acid vectors that comprise one or more modifications within at least one inverted terminal repeat (ITR) region. Exemplary modifications include ITR sequences comprising a glucocorticoid responsive element and/or a transcription factor binding site. Also provided are plasmids, libraries, rAAV particles, compositions, kits, and methods related to such vectors.