公开(公告)号：US20230181746A1

公开(公告)日：2023-06-15

申请号：US17925776

申请日：2021-05-17

Applicant: University of Florida Research Foundation, Inc.

Inventor： Daiqing LIAO ,  Yufeng XIAO ,  Xuan ZHANG ,  Guangrong ZHENG

IPC: A61K47/55 ,  A61P35/00 ,  A61K47/60

CPC classification number: A61K47/55 ,  A61P35/00 ,  A61K47/60

Abstract: In one aspect, the disclosure relates to benzoylhydrazide-derived PROTACs that are highly effective at degrading HDAC3 and that are also capable of targeting, to a lesser extent, other HDAC isoforms, methods of making same, pharmaceutical compositions comprising same, and methods of treating cancers including hematologic cancers, breast cancer, other malignancies, and other serious diseases involving aberrant HDAC activity using the same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.